Osteoarthritis: The relationship with your immune system

Osteoarthritis (OA) is a common degenerative disease. It is the result of wear and tear in the joint and affects the elderly population. In spite of the fact that OA used to be considered as a condition that only affected older population. Its onset occurs far earlier. And is now included among the top 20 illnesses affecting those aged 40 to 45. About 250 million individuals, or 4% of the world’s population are overwhelmed with Osteoarthritis. Clinical presentations included low grade inflammation, swelling, deformity of the joint and muscle degradation.

Causes:

• Process of wear and tear.

• Past injuries.

• Overweight.

• Autoimmune disorder.

• Hyperthyroid. 

• Use of antibiotic.

• Repetitive postural dysfunction.

Role of immune system in Osteoarthritis

The innate immune system activation is involved in the initiation and perpetuation of a low-grade inflammation. Altogether OA pathology is the result of an imbalance, between the anabolic and catabolic processes in the joint. Therefore, damage to cartilage extracellular matrix products from trauma or normal aging generates activate the innate immune system.

Types of patients mostly affected:

1. Anyone can get osteoarthritis, but it is more common as people age.

2. Women are more likely than men to have osteoarthritis.

3. Especially after age 50.

4. Overweight or obesity.

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